diff --git a/OvmfPkg/OvmfPkgIa32.dsc b/OvmfPkg/OvmfPkgIa32.dsc
index 11e1f98f1a..ba7ba49d82 100644
--- a/OvmfPkg/OvmfPkgIa32.dsc
+++ b/OvmfPkg/OvmfPkgIa32.dsc
@@ -29,6 +29,11 @@
   SKUID_IDENTIFIER               = DEFAULT
   FLASH_DEFINITION               = OvmfPkg/OvmfPkg.fdf
 
+[BuildOptions]
+  GCC:*_*_*_CC_FLAGS             = -DMDEPKG_NDEBUG
+  INTEL:*_*_*_CC_FLAGS           = /D MDEPKG_NDEBUG
+  MSFT:*_*_*_CC_FLAGS            = /D MDEPKG_NDEBUG
+
 ################################################################################
 #
 # SKU Identification section - list of all SKU IDs supported by this Platform.
diff --git a/OvmfPkg/OvmfPkgIa32X64.dsc b/OvmfPkg/OvmfPkgIa32X64.dsc
index 55fc6ce0b0..a96064ed5d 100644
--- a/OvmfPkg/OvmfPkgIa32X64.dsc
+++ b/OvmfPkg/OvmfPkgIa32X64.dsc
@@ -29,6 +29,11 @@
   SKUID_IDENTIFIER               = DEFAULT
   FLASH_DEFINITION               = OvmfPkg/OvmfPkgIa32X64.fdf
 
+[BuildOptions]
+  GCC:*_*_*_CC_FLAGS             = -DMDEPKG_NDEBUG
+  INTEL:*_*_*_CC_FLAGS           = /D MDEPKG_NDEBUG
+  MSFT:*_*_*_CC_FLAGS            = /D MDEPKG_NDEBUG
+
 ################################################################################
 #
 # SKU Identification section - list of all SKU IDs supported by this Platform.
diff --git a/OvmfPkg/OvmfPkgX64.dsc b/OvmfPkg/OvmfPkgX64.dsc
index 4d82980fe2..b0defc3d80 100644
--- a/OvmfPkg/OvmfPkgX64.dsc
+++ b/OvmfPkg/OvmfPkgX64.dsc
@@ -29,6 +29,11 @@
   SKUID_IDENTIFIER               = DEFAULT
   FLASH_DEFINITION               = OvmfPkg/OvmfPkg.fdf
 
+[BuildOptions]
+  GCC:*_*_*_CC_FLAGS             = -DMDEPKG_NDEBUG
+  INTEL:*_*_*_CC_FLAGS           = /D MDEPKG_NDEBUG
+  MSFT:*_*_*_CC_FLAGS            = /D MDEPKG_NDEBUG
+
 ################################################################################
 #
 # SKU Identification section - list of all SKU IDs supported by this Platform.