diff --git a/MdeModulePkg/Core/Dxe/Hand/Handle.c b/MdeModulePkg/Core/Dxe/Hand/Handle.c
index b5ff3fdcd1..93e69eea73 100644
--- a/MdeModulePkg/Core/Dxe/Hand/Handle.c
+++ b/MdeModulePkg/Core/Dxe/Hand/Handle.c
@@ -1107,6 +1107,8 @@ CoreOpenProtocol (
     return EFI_INVALID_PARAMETER;
   }
 
+  Prot = NULL;
+
   //
   // Lock the protocol database
   //