diff --git a/MdeModulePkg/Include/Guid/S3StorageDeviceInitList.h b/MdeModulePkg/Include/Guid/S3StorageDeviceInitList.h
new file mode 100644
index 0000000000..bd300b2696
--- /dev/null
+++ b/MdeModulePkg/Include/Guid/S3StorageDeviceInitList.h
@@ -0,0 +1,64 @@
+/** @file
+  Define the LockBox GUID for list of storage devices need to be initialized in
+  S3.
+
+  Copyright (c) 2019, Intel Corporation. All rights reserved.<BR>
+
+  This program and the accompanying materials
+  are licensed and made available under the terms and conditions
+  of the BSD License which accompanies this distribution.  The
+  full text of the license may be found at
+  http://opensource.org/licenses/bsd-license.php
+
+  THE PROGRAM IS DISTRIBUTED UNDER THE BSD LICENSE ON AN "AS IS" BASIS,
+  WITHOUT WARRANTIES OR REPRESENTATIONS OF ANY KIND, EITHER EXPRESS OR IMPLIED.
+
+**/
+
+#ifndef __S3_STORAGE_DEVICE_INIT_LIST_H__
+#define __S3_STORAGE_DEVICE_INIT_LIST_H__
+
+#define S3_STORAGE_DEVICE_INIT_LIST \
+  { \
+    0x310e9b8c, 0xcf90, 0x421e, { 0x8e, 0x9b, 0x9e, 0xef, 0xb6, 0x17, 0xc8, 0xef } \
+  }
+
+//
+// The LockBox will store a DevicePath structure that contains one or more
+// DevicePath instances. Each instance denotes a storage device that needs to
+// get initialized during the S3 resume.
+//
+// For example, if there is only one storage device stored in the list, the
+// content of this LockBox will be:
+//
+// +-------------------------------------------------------+
+// |                 DevPath Instance #1                   |
+// | (Terminated by an End of Hardware Device Path node    |
+// |  with an End Entire Device Path sub-type)             |
+// +-------------------------------------------------------+
+//
+// If there are n (n > 1) storage devices in the list, the content of this
+// LockBox will be:
+//
+// +-------------------------------------------------------+
+// |                 DevPath Instance #1                   |
+// | (Terminated by an End of Hardware Device Path node    |
+// |  with an End This Instance of a Device Path sub-type) |
+// +-------------------------------------------------------+
+// |                 DevPath Instance #2                   |
+// | (Terminated by an End of Hardware Device Path node    |
+// |  with an End This Instance of a Device Path sub-type) |
+// +-------------------------------------------------------+
+// |                        ...                            |
+// +-------------------------------------------------------+
+// |                 DevPath Instance #n                   |
+// | (Terminated by an End of Hardware Device Path node    |
+// |  with an End Entire Device Path sub-type)             |
+// +-------------------------------------------------------+
+//
+// The attribute of the LockBox should be set to
+// 'LOCK_BOX_ATTRIBUTE_RESTORE_IN_S3_ONLY'.
+//
+extern EFI_GUID  gS3StorageDeviceInitListGuid;
+
+#endif  // __S3_STORAGE_DEVICE_INIT_LIST_H__
diff --git a/MdeModulePkg/MdeModulePkg.dec b/MdeModulePkg/MdeModulePkg.dec
index 7f646d7702..a2130bc439 100644
--- a/MdeModulePkg/MdeModulePkg.dec
+++ b/MdeModulePkg/MdeModulePkg.dec
@@ -422,6 +422,9 @@
   ## Include/Guid/S3SmmInitDone.h
   gEdkiiS3SmmInitDoneGuid = { 0x8f9d4825, 0x797d, 0x48fc, { 0x84, 0x71, 0x84, 0x50, 0x25, 0x79, 0x2e, 0xf6 } }
 
+  ## Include/Guid/S3StorageDeviceInitList.h
+  gS3StorageDeviceInitListGuid = { 0x310e9b8c, 0xcf90, 0x421e, { 0x8e, 0x9b, 0x9e, 0xef, 0xb6, 0x17, 0xc8, 0xef } }
+
 [Ppis]
   ## Include/Ppi/AtaController.h
   gPeiAtaControllerPpiGuid       = { 0xa45e60d1, 0xc719, 0x44aa, { 0xb0, 0x7a, 0xaa, 0x77, 0x7f, 0x85, 0x90, 0x6d }}