diff --git a/MdeModulePkg/Universal/Variable/RuntimeDxe/VariableRuntimeDxe.inf b/MdeModulePkg/Universal/Variable/RuntimeDxe/VariableRuntimeDxe.inf
index da40ba1e07..d818ff04a0 100644
--- a/MdeModulePkg/Universal/Variable/RuntimeDxe/VariableRuntimeDxe.inf
+++ b/MdeModulePkg/Universal/Variable/RuntimeDxe/VariableRuntimeDxe.inf
@@ -73,5 +73,5 @@
   gEfiMdeModulePkgTokenSpaceGuid.PcdVariableCollectStatistics
 
 [Depex]
-  gEfiFirmwareVolumeBlockProtocolGuid AND gEfiAlternateFvBlockGuid AND gEfiFaultTolerantWriteLiteProtocolGuid
+  gEfiFirmwareVolumeBlockProtocolGuid AND gEfiFaultTolerantWriteLiteProtocolGuid