diff --git a/MdePkg/Include/Protocol/DevicePathFromText.h b/MdePkg/Include/Protocol/DevicePathFromText.h
index ffac715978..d9a9aeae1e 100644
--- a/MdePkg/Include/Protocol/DevicePathFromText.h
+++ b/MdePkg/Include/Protocol/DevicePathFromText.h
@@ -16,8 +16,6 @@
 #ifndef __DEVICE_PATH_FROM_TEXT_PROTOCOL_H__
 #define __DEVICE_PATH_FROM_TEXT_PROTOCOL_H__
 
-#include <Protocol/DevicePath.h>
-
 ///
 /// Device Path From Text protocol
 ///
diff --git a/MdePkg/Include/Protocol/DevicePathToText.h b/MdePkg/Include/Protocol/DevicePathToText.h
index 4767e08c93..bbc348398a 100644
--- a/MdePkg/Include/Protocol/DevicePathToText.h
+++ b/MdePkg/Include/Protocol/DevicePathToText.h
@@ -16,8 +16,6 @@
 #ifndef __DEVICE_PATH_TO_TEXT_PROTOCOL_H__
 #define __DEVICE_PATH_TO_TEXT_PROTOCOL_H__
 
-#include <Protocol/DevicePath.h>
-
 ///
 /// Device Path To Text protocol
 ///
diff --git a/MdePkg/Include/Protocol/DevicePathUtilities.h b/MdePkg/Include/Protocol/DevicePathUtilities.h
index ba430d3a15..48e06aab0a 100644
--- a/MdePkg/Include/Protocol/DevicePathUtilities.h
+++ b/MdePkg/Include/Protocol/DevicePathUtilities.h
@@ -16,9 +16,6 @@
 #ifndef __DEVICE_PATH_UTILITIES_PROTOCOL_H__
 #define __DEVICE_PATH_UTILITIES_PROTOCOL_H__
 
-
-#include <Protocol/DevicePath.h>
-
 ///
 /// Device Path Utilities protocol
 ///
diff --git a/MdePkg/Include/Protocol/DriverBinding.h b/MdePkg/Include/Protocol/DriverBinding.h
index 475988c904..2b7eb31ea7 100644
--- a/MdePkg/Include/Protocol/DriverBinding.h
+++ b/MdePkg/Include/Protocol/DriverBinding.h
@@ -18,7 +18,6 @@
 #ifndef __EFI_DRIVER_BINDING_H__
 #define __EFI_DRIVER_BINDING_H__
 
-#include <Protocol/DevicePath.h>
 ///
 /// Global ID for the ControllerHandle Driver Protocol
 ///
diff --git a/MdePkg/Include/Protocol/HiiString.h b/MdePkg/Include/Protocol/HiiString.h
index 406c6fa22d..d0b7e0d221 100644
--- a/MdePkg/Include/Protocol/HiiString.h
+++ b/MdePkg/Include/Protocol/HiiString.h
@@ -15,12 +15,10 @@
 #ifndef __HII_STRING_H__
 #define __HII_STRING_H__
 
-#define EFI_HII_STRING_PROTOCOL_GUID \
-  { 0xfd96974, 0x23aa, 0x4cdc, { 0xb9, 0xcb, 0x98, 0xd1, 0x77, 0x50, 0x32, 0x2a } }
-
-#include <Protocol/HiiDatabase.h>
 #include <Protocol/HiiFont.h>
 
+#define EFI_HII_STRING_PROTOCOL_GUID \
+  { 0xfd96974, 0x23aa, 0x4cdc, { 0xb9, 0xcb, 0x98, 0xd1, 0x77, 0x50, 0x32, 0x2a } }
 
 typedef struct _EFI_HII_STRING_PROTOCOL EFI_HII_STRING_PROTOCOL;
 
diff --git a/MdePkg/Include/Protocol/LoadedImage.h b/MdePkg/Include/Protocol/LoadedImage.h
index 9a2a94ab0b..f95c045ca6 100644
--- a/MdePkg/Include/Protocol/LoadedImage.h
+++ b/MdePkg/Include/Protocol/LoadedImage.h
@@ -18,8 +18,6 @@
 #ifndef __LOADED_IMAGE_PROTOCOL_H__
 #define __LOADED_IMAGE_PROTOCOL_H__
 
-#include <Protocol/DevicePath.h>
-
 #define EFI_LOADED_IMAGE_PROTOCOL_GUID \
   { \
     0x5B1B31A1, 0x9562, 0x11d2, {0x8E, 0x3F, 0x00, 0xA0, 0xC9, 0x69, 0x72, 0x3B } \
diff --git a/MdePkg/Include/Protocol/Usb2HostController.h b/MdePkg/Include/Protocol/Usb2HostController.h
index bb550a381d..9137370dd1 100644
--- a/MdePkg/Include/Protocol/Usb2HostController.h
+++ b/MdePkg/Include/Protocol/Usb2HostController.h
@@ -18,7 +18,6 @@
 #ifndef _USB2_HOSTCONTROLLER_H_
 #define _USB2_HOSTCONTROLLER_H_
 
-#include <IndustryStandard/Usb.h>
 #include <Protocol/UsbIo.h>
 
 #define EFI_USB2_HC_PROTOCOL_GUID \
diff --git a/MdePkg/Library/UefiDevicePathLib/UefiDevicePathLib.c b/MdePkg/Library/UefiDevicePathLib/UefiDevicePathLib.c
index 46c5c058f3..5aad01f993 100644
--- a/MdePkg/Library/UefiDevicePathLib/UefiDevicePathLib.c
+++ b/MdePkg/Library/UefiDevicePathLib/UefiDevicePathLib.c
@@ -22,8 +22,6 @@
 
 #include <Uefi.h>
 
-#include <Protocol/DevicePath.h>
-
 #include <Library/DevicePathLib.h>
 #include <Library/BaseMemoryLib.h>
 #include <Library/DebugLib.h>
diff --git a/MdePkg/Library/UefiDevicePathLibDevicePathProtocol/UefiDevicePathLib.c b/MdePkg/Library/UefiDevicePathLibDevicePathProtocol/UefiDevicePathLib.c
index 6ff6335fda..9f9a470991 100644
--- a/MdePkg/Library/UefiDevicePathLibDevicePathProtocol/UefiDevicePathLib.c
+++ b/MdePkg/Library/UefiDevicePathLibDevicePathProtocol/UefiDevicePathLib.c
@@ -17,7 +17,6 @@
 #include <Uefi.h>
 
 #include <Protocol/DevicePathUtilities.h>
-#include <Protocol/DevicePath.h>
 
 #include <Library/DevicePathLib.h>
 #include <Library/DebugLib.h>