diff --git a/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskBlockIo.c b/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskBlockIo.c
index 4f74b5ef15..8926ad7d2f 100644
--- a/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskBlockIo.c
+++ b/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskBlockIo.c
@@ -1,7 +1,7 @@
 /** @file
   Produce EFI_BLOCK_IO_PROTOCOL on a RAM disk device.
 
-  Copyright (c) 2016 - 2018, Intel Corporation. All rights reserved.<BR>
+  Copyright (c) 2016 - 2019, Intel Corporation. All rights reserved.<BR>
   This program and the accompanying materials
   are licensed and made available under the terms and conditions of the BSD License
   which accompanies this distribution.  The full text of the license may be found at
@@ -54,6 +54,7 @@ RamDiskInitBlockIo (
   EFI_BLOCK_IO_PROTOCOL           *BlockIo;
   EFI_BLOCK_IO2_PROTOCOL          *BlockIo2;
   EFI_BLOCK_IO_MEDIA              *Media;
+  UINT32                          Remainder;
 
   BlockIo  = &PrivateData->BlockIo;
   BlockIo2 = &PrivateData->BlockIo2;
@@ -69,11 +70,18 @@ RamDiskInitBlockIo (
   Media->LogicalPartition = FALSE;
   Media->ReadOnly         = FALSE;
   Media->WriteCaching     = FALSE;
-  Media->BlockSize        = RAM_DISK_BLOCK_SIZE;
-  Media->LastBlock        = DivU64x32 (
-                              PrivateData->Size + RAM_DISK_BLOCK_SIZE - 1,
-                              RAM_DISK_BLOCK_SIZE
-                              ) - 1;
+
+  for (Media->BlockSize = RAM_DISK_DEFAULT_BLOCK_SIZE;
+       Media->BlockSize >= 1;
+       Media->BlockSize = Media->BlockSize >> 1) {
+    Media->LastBlock = DivU64x32Remainder (PrivateData->Size, Media->BlockSize, &Remainder) - 1;
+    if (Remainder == 0) {
+      break;
+    }
+  }
+  ASSERT (Media->BlockSize != 0);
+
+  return;
 }
 
 
diff --git a/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskImpl.h b/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskImpl.h
index 08a8ca94c9..72f2bfe179 100644
--- a/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskImpl.h
+++ b/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskImpl.h
@@ -1,7 +1,7 @@
 /** @file
   The header file of RamDiskDxe driver.
 
-  Copyright (c) 2016, Intel Corporation. All rights reserved.<BR>
+  Copyright (c) 2016 - 2019, Intel Corporation. All rights reserved.<BR>
   This program and the accompanying materials
   are licensed and made available under the terms and conditions of the BSD License
   which accompanies this distribution.  The full text of the license may be found at
@@ -49,9 +49,9 @@
 ///
 
 //
-// Block size for RAM disk
+// Default block size for RAM disk
 //
-#define RAM_DISK_BLOCK_SIZE 512
+#define RAM_DISK_DEFAULT_BLOCK_SIZE 512
 
 //
 // Iterate through the double linked list. NOT delete safe
diff --git a/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskProtocol.c b/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskProtocol.c
index 6784e2b2f1..e8250d5c1b 100644
--- a/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskProtocol.c
+++ b/MdeModulePkg/Universal/Disk/RamDiskDxe/RamDiskProtocol.c
@@ -1,7 +1,7 @@
 /** @file
   The realization of EFI_RAM_DISK_PROTOCOL.
 
-  Copyright (c) 2016, Intel Corporation. All rights reserved.<BR>
+  Copyright (c) 2016 - 2019, Intel Corporation. All rights reserved.<BR>
   (C) Copyright 2016 Hewlett Packard Enterprise Development LP<BR>
   This program and the accompanying materials
   are licensed and made available under the terms and conditions of the BSD License
@@ -613,7 +613,8 @@ RamDiskRegister (
   //
   // Add check to prevent data read across the memory boundary
   //
-  if (RamDiskBase + RamDiskSize > ((UINTN) -1) - RAM_DISK_BLOCK_SIZE + 1) {
+  if ((RamDiskSize > MAX_UINTN) ||
+      (RamDiskBase > MAX_UINTN - RamDiskSize + 1)) {
     return EFI_INVALID_PARAMETER;
   }