diff --git a/MdePkg/Include/Base.h b/MdePkg/Include/Base.h
index 0e722ec7ab..d95fb0b850 100644
--- a/MdePkg/Include/Base.h
+++ b/MdePkg/Include/Base.h
@@ -454,7 +454,7 @@ struct _LIST_ENTRY {
 
 #define VA_END(Marker)                ((void)0)
 
-#elif defined(__GNUC__)
+#elif defined(__GNUC__) && !defined(NO_BUILTIN_VA_FUNCS)
 //
 // Use GCC built-in macros for variable argument lists.
 //