diff --git a/MdePkg/Include/AArch64/ProcessorBind.h b/MdePkg/Include/AArch64/ProcessorBind.h
index 775e7498c5..7b0f0ff32f 100644
--- a/MdePkg/Include/AArch64/ProcessorBind.h
+++ b/MdePkg/Include/AArch64/ProcessorBind.h
@@ -26,7 +26,7 @@
 //
 // Make sure we are using the correct packing rules per EFI specification
 //
-#ifndef __GNUC__
+#if !defined(__GNUC__) && !defined(__ASSEMBLER__)
 #pragma pack()
 #endif
 
diff --git a/MdePkg/Include/Arm/ProcessorBind.h b/MdePkg/Include/Arm/ProcessorBind.h
index dde1fd1152..42ea2f3055 100644
--- a/MdePkg/Include/Arm/ProcessorBind.h
+++ b/MdePkg/Include/Arm/ProcessorBind.h
@@ -24,7 +24,7 @@
 //
 // Make sure we are using the correct packing rules per EFI specification
 //
-#ifndef __GNUC__
+#if !defined(__GNUC__) && !defined(__ASSEMBLER__)
 #pragma pack()
 #endif