diff --git a/ArmPkg/Library/DebugPeCoffExtraActionLib/DebugPeCoffExtraActionLib.c b/ArmPkg/Library/DebugPeCoffExtraActionLib/DebugPeCoffExtraActionLib.c
index 432112354f..c5c53ef3e1 100644
--- a/ArmPkg/Library/DebugPeCoffExtraActionLib/DebugPeCoffExtraActionLib.c
+++ b/ArmPkg/Library/DebugPeCoffExtraActionLib/DebugPeCoffExtraActionLib.c
@@ -71,7 +71,7 @@ PeCoffLoaderRelocateImageExtraAction (
   IN OUT PE_COFF_LOADER_IMAGE_CONTEXT  *ImageContext
   )
 {
- #if !defined (MDEPKG_NDEBUG)
+ #if defined (__CC_ARM) || defined (__GNUC__)
   CHAR8  Temp[512];
  #endif
 
@@ -106,7 +106,7 @@ PeCoffLoaderUnloadImageExtraAction (
   IN OUT PE_COFF_LOADER_IMAGE_CONTEXT  *ImageContext
   )
 {
- #if !defined (MDEPKG_NDEBUG)
+ #if defined (__CC_ARM) || defined (__GNUC__)
   CHAR8  Temp[512];
  #endif
 
diff --git a/ArmPkg/Library/DefaultExceptionHandlerLib/AArch64/DefaultExceptionHandler.c b/ArmPkg/Library/DefaultExceptionHandlerLib/AArch64/DefaultExceptionHandler.c
index a39896d576..1d3ea61311 100644
--- a/ArmPkg/Library/DefaultExceptionHandlerLib/AArch64/DefaultExceptionHandler.c
+++ b/ArmPkg/Library/DefaultExceptionHandlerLib/AArch64/DefaultExceptionHandler.c
@@ -157,7 +157,6 @@ DescribeExceptionSyndrome (
   DEBUG ((DEBUG_ERROR, "\n %a \n", Message));
 }
 
-#ifndef MDEPKG_NDEBUG
 STATIC
 CONST CHAR8 *
 BaseName (
@@ -177,8 +176,6 @@ BaseName (
   return Str;
 }
 
-#endif
-
 /**
   This is the default action to take on an unexpected exception
 
diff --git a/MdePkg/Include/Library/DebugLib.h b/MdePkg/Include/Library/DebugLib.h
index f0c9f64487..86a939c42f 100644
--- a/MdePkg/Include/Library/DebugLib.h
+++ b/MdePkg/Include/Library/DebugLib.h
@@ -403,7 +403,12 @@ UnitTestDebugAssert (
       }                             \
     } while (FALSE)
 #else
-#define ASSERT(Expression)
+#define ASSERT(Expression)       \
+    do {                           \
+      if ((FALSE)) {               \
+        (VOID) (Expression);       \
+      }                            \
+    } while (FALSE)
 #endif
 
 /**
@@ -425,6 +430,16 @@ UnitTestDebugAssert (
         _DEBUG (Expression);       \
       }                            \
     } while (FALSE)
+#elif defined (__GNUC__) || defined (__clang__)
+#define DEBUG(Expression)                                \
+    do {                                                   \
+      _Pragma("GCC diagnostic push")                       \
+      _Pragma("GCC diagnostic ignored \"-Wunused-value\"") \
+      if ((FALSE)) {                                       \
+        (VOID) Expression;                                 \
+      }                                                    \
+      _Pragma("GCC diagnostic pop")                        \
+    } while (FALSE)
 #else
 #define DEBUG(Expression)
 #endif
@@ -452,7 +467,12 @@ UnitTestDebugAssert (
       }                                                                                  \
     } while (FALSE)
 #else
-#define ASSERT_EFI_ERROR(StatusParameter)
+#define ASSERT_EFI_ERROR(StatusParameter)                                             \
+    do {                                                                                \
+      if ((FALSE)) {                                                                    \
+        (VOID) (StatusParameter);                                                       \
+      }                                                                                 \
+    } while (FALSE)
 #endif
 
 /**
@@ -479,7 +499,12 @@ UnitTestDebugAssert (
       }                                                                 \
     } while (FALSE)
 #else
-#define ASSERT_RETURN_ERROR(StatusParameter)
+#define ASSERT_RETURN_ERROR(StatusParameter)                          \
+    do {                                                                \
+      if ((FALSE)) {                                                    \
+        (VOID) (StatusParameter);                                       \
+      }                                                                 \
+    } while (FALSE)
 #endif
 
 /**
@@ -534,7 +559,12 @@ UnitTestDebugAssert (
   are not included in a module.
 
 **/
-#define DEBUG_CODE_BEGIN()  do { if (DebugCodeEnabled ()) { UINT8  __DebugCodeLocal
+#define DEBUG_CODE_BEGIN()      \
+  do {                          \
+    BOOLEAN  __DebugCodeLocal;  \
+    __DebugCodeLocal = FALSE;   \
+    do {                        \
+      if (DebugCodeEnabled ()) {
 
 /**
   The macro that marks the end of debug source code.
@@ -545,7 +575,10 @@ UnitTestDebugAssert (
   are not included in a module.
 
 **/
-#define DEBUG_CODE_END()  __DebugCodeLocal = 0; __DebugCodeLocal++; } } while (FALSE)
+#define DEBUG_CODE_END()         \
+      }                          \
+    } while (__DebugCodeLocal);  \
+  } while (FALSE)
 
 /**
   The macro that declares a section of debug source code.
diff --git a/MdePkg/Include/Library/PerformanceLib.h b/MdePkg/Include/Library/PerformanceLib.h
index d0f2dfb070..57ba45eb7b 100644
--- a/MdePkg/Include/Library/PerformanceLib.h
+++ b/MdePkg/Include/Library/PerformanceLib.h
@@ -734,7 +734,12 @@ LogPerformanceMeasurement (
   Otherwise, the source lines between PERF_CODE_BEGIN() and PERF_CODE_END() are not included in a module.
 
 **/
-#define PERF_CODE_BEGIN()  do { if (PerformanceMeasurementEnabled ()) { UINT8  __PerformanceCodeLocal
+#define PERF_CODE_BEGIN()            \
+  do {                               \
+    BOOLEAN  __PerformanceCodeLocal; \
+    __PerformanceCodeLocal = FALSE;  \
+    do {                             \
+      if (PerformanceMeasurementEnabled ()) {
 
 /**
   Macro that marks the end of performance measurement source code.
@@ -744,7 +749,10 @@ LogPerformanceMeasurement (
   Otherwise, the source lines between PERF_CODE_BEGIN() and PERF_CODE_END() are not included in a module.
 
 **/
-#define PERF_CODE_END()  __PerformanceCodeLocal = 0; __PerformanceCodeLocal++; } } while (FALSE)
+#define PERF_CODE_END()                \
+      }                                \
+    } while (__PerformanceCodeLocal);  \
+  } while (FALSE)
 
 /**
   Macro that declares a section of performance measurement source code.