diff --git a/BaseTools/Source/Python/Common/GlobalData.py b/BaseTools/Source/Python/Common/GlobalData.py
index fac7cde708..57048bcae6 100644
--- a/BaseTools/Source/Python/Common/GlobalData.py
+++ b/BaseTools/Source/Python/Common/GlobalData.py
@@ -66,6 +66,13 @@ gHexPatternAll = re.compile(r'0[xX]{}+$'.format(_HexChar))
 
 ## Regular expressions for string identifier checking
 gIdentifierPattern = re.compile('^[a-zA-Z][a-zA-Z0-9_]*$', re.UNICODE)
+## Regular expression for GUID c structure format
+_GuidCFormatPattern = r"{{\s*0[xX]{Hex}{{1,8}}\s*,\s*0[xX]{Hex}{{1,4}}\s*,\s*0[xX]{Hex}{{1,4}}" \
+                      r"\s*,\s*{{\s*0[xX]{Hex}{{1,2}}\s*,\s*0[xX]{Hex}{{1,2}}" \
+                      r"\s*,\s*0[xX]{Hex}{{1,2}}\s*,\s*0[xX]{Hex}{{1,2}}" \
+                      r"\s*,\s*0[xX]{Hex}{{1,2}}\s*,\s*0[xX]{Hex}{{1,2}}" \
+                      r"\s*,\s*0[xX]{Hex}{{1,2}}\s*,\s*0[xX]{Hex}{{1,2}}\s*}}\s*}}".format(Hex=_HexChar)
+gGuidCFormatPattern = re.compile(r"{}".format(_GuidCFormatPattern))
 
 #
 # A global variable for whether current build in AutoGen phase or not.
diff --git a/BaseTools/Source/Python/Common/Misc.py b/BaseTools/Source/Python/Common/Misc.py
index 430bf6bcda..fc90ccb2c8 100644
--- a/BaseTools/Source/Python/Common/Misc.py
+++ b/BaseTools/Source/Python/Common/Misc.py
@@ -360,6 +360,8 @@ def GuidStructureByteArrayToGuidString(GuidValue):
 #   @retval     string      The GUID value in xxxxxxxx-xxxx-xxxx-xxxx-xxxxxxxxxxxx format
 #
 def GuidStructureStringToGuidString(GuidValue):
+    if not GlobalData.gGuidCFormatPattern.match(GuidValue):
+        return ''
     guidValueString = GuidValue.lower().replace("{", "").replace("}", "").replace(" ", "").replace(";", "")
     guidValueList = guidValueString.split(",")
     if len(guidValueList) != 11:
@@ -1327,7 +1329,7 @@ def ParseFieldValue (Value):
         Value = Value.split('(', 1)[1][:-1].strip()
         if Value[0] == '{' and Value[-1] == '}':
             TmpValue = GuidStructureStringToGuidString(Value)
-            if len(TmpValue) == 0:
+            if not TmpValue:
                 raise BadExpression("Invalid GUID value string %s" % Value)
             Value = TmpValue
         if Value[0] == '"' and Value[-1] == '"':