diff --git a/MdePkg/Include/Base.h b/MdePkg/Include/Base.h
index 554f827fd1..a6fb59205e 100644
--- a/MdePkg/Include/Base.h
+++ b/MdePkg/Include/Base.h
@@ -800,12 +800,14 @@ typedef UINTN *BASE_LIST;
   @param  Message     Raised compiler diagnostic message when expression is false.
 
 **/
-#ifdef MDE_CPU_EBC
-#define STATIC_ASSERT(Expression, Message)
-#elif defined (_MSC_EXTENSIONS) || defined (__cplusplus)
+#if defined (__cplusplus)
+#define STATIC_ASSERT  static_assert
+#elif defined (__GNUC__) || defined (__clang__)
+#define STATIC_ASSERT  _Static_assert
+#elif defined (_MSC_EXTENSIONS)
 #define STATIC_ASSERT  static_assert
 #else
-#define STATIC_ASSERT  _Static_assert
+  #error STATIC_ASSERT() definiton not available
 #endif
 
 //