diff --git a/CryptoPkg/Library/Include/openssl/opensslconf.h b/CryptoPkg/Library/Include/openssl/opensslconf.h
index bd34e53ef2..70d24f99ac 100644
--- a/CryptoPkg/Library/Include/openssl/opensslconf.h
+++ b/CryptoPkg/Library/Include/openssl/opensslconf.h
@@ -61,6 +61,9 @@ extern "C" {
 #ifndef OPENSSL_NO_MD2
 # define OPENSSL_NO_MD2
 #endif
+#ifndef OPENSSL_NO_MD4
+# define OPENSSL_NO_MD4
+#endif
 #ifndef OPENSSL_NO_MDC2
 # define OPENSSL_NO_MDC2
 #endif
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLib.inf b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
index 9ed0175553..10710e4a7c 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLib.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
@@ -294,8 +294,6 @@
   $(OPENSSL_PATH)/crypto/kdf/tls1_prf.c
   $(OPENSSL_PATH)/crypto/lhash/lh_stats.c
   $(OPENSSL_PATH)/crypto/lhash/lhash.c
-  $(OPENSSL_PATH)/crypto/md4/md4_dgst.c
-  $(OPENSSL_PATH)/crypto/md4/md4_one.c
   $(OPENSSL_PATH)/crypto/md5/md5_dgst.c
   $(OPENSSL_PATH)/crypto/md5/md5_one.c
   $(OPENSSL_PATH)/crypto/mem.c
@@ -525,7 +523,6 @@
   $(OPENSSL_PATH)/crypto/evp/evp_locl.h
   $(OPENSSL_PATH)/crypto/hmac/hmac_lcl.h
   $(OPENSSL_PATH)/crypto/lhash/lhash_lcl.h
-  $(OPENSSL_PATH)/crypto/md4/md4_locl.h
   $(OPENSSL_PATH)/crypto/md5/md5_locl.h
   $(OPENSSL_PATH)/crypto/modes/modes_lcl.h
   $(OPENSSL_PATH)/crypto/objects/obj_dat.h
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf b/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
index 03da266627..d9782a3098 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
@@ -294,8 +294,6 @@
   $(OPENSSL_PATH)/crypto/kdf/tls1_prf.c
   $(OPENSSL_PATH)/crypto/lhash/lh_stats.c
   $(OPENSSL_PATH)/crypto/lhash/lhash.c
-  $(OPENSSL_PATH)/crypto/md4/md4_dgst.c
-  $(OPENSSL_PATH)/crypto/md4/md4_one.c
   $(OPENSSL_PATH)/crypto/md5/md5_dgst.c
   $(OPENSSL_PATH)/crypto/md5/md5_one.c
   $(OPENSSL_PATH)/crypto/mem.c
@@ -525,7 +523,6 @@
   $(OPENSSL_PATH)/crypto/evp/evp_locl.h
   $(OPENSSL_PATH)/crypto/hmac/hmac_lcl.h
   $(OPENSSL_PATH)/crypto/lhash/lhash_lcl.h
-  $(OPENSSL_PATH)/crypto/md4/md4_locl.h
   $(OPENSSL_PATH)/crypto/md5/md5_locl.h
   $(OPENSSL_PATH)/crypto/modes/modes_lcl.h
   $(OPENSSL_PATH)/crypto/objects/obj_dat.h
diff --git a/CryptoPkg/Library/OpensslLib/process_files.pl b/CryptoPkg/Library/OpensslLib/process_files.pl
index 4ba25da407..bd4a84da24 100755
--- a/CryptoPkg/Library/OpensslLib/process_files.pl
+++ b/CryptoPkg/Library/OpensslLib/process_files.pl
@@ -73,6 +73,7 @@ BEGIN {
                 "no-gost",
                 "no-hw",
                 "no-idea",
+                "no-md4",
                 "no-mdc2",
                 "no-pic",
                 "no-ocb",