diff --git a/CryptoPkg/Library/OpensslLib/OpensslLib.inf b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
index ff81460d03..a9e793a940 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLib.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
@@ -509,7 +509,7 @@
   INTEL:*_*_IPF_CC_FLAGS    = -U_WIN32 -U_WIN64 -U_MSC_VER -U__ICC $(OPENSSL_FLAGS) /w
 
   GCC:*_*_IA32_CC_FLAGS     = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) -w
-  GCC:*_*_X64_CC_FLAGS      = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) -w -UNO_BUILTIN_VA_FUNCS
+  GCC:*_*_X64_CC_FLAGS      = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) -w -UNO_BUILTIN_VA_FUNCS -DNO_MSABI_VA_FUNCS
   GCC:*_*_IPF_CC_FLAGS      = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) -w
   GCC:*_*_ARM_CC_FLAGS      = $(OPENSSL_FLAGS) -w
   GCC:*_*_AARCH64_CC_FLAGS  = $(OPENSSL_FLAGS) -w