diff --git a/MdeModulePkg/Bus/Pci/PciBusDxe/PciEnumeratorSupport.c b/MdeModulePkg/Bus/Pci/PciBusDxe/PciEnumeratorSupport.c
index a6ade26e3a..086c481130 100644
--- a/MdeModulePkg/Bus/Pci/PciBusDxe/PciEnumeratorSupport.c
+++ b/MdeModulePkg/Bus/Pci/PciBusDxe/PciEnumeratorSupport.c
@@ -164,6 +164,14 @@ PciPciDeviceInfoCollector (
             return Status;
           }
 
+          //
+          // Ensure secondary bus number is greater than the primary bus number to avoid
+          // any potential dead loop when PcdPciDisableBusEnumeration is set to TRUE
+          //
+          if (SecBus <= StartBusNumber) {
+            break;
+          }
+
           //
           // Get resource padding for PPB
           //