diff --git a/MdeModulePkg/Bus/Pci/PciSioSerialDxe/Serial.c b/MdeModulePkg/Bus/Pci/PciSioSerialDxe/Serial.c
index e8cefecd8d..aeafee247c 100644
--- a/MdeModulePkg/Bus/Pci/PciSioSerialDxe/Serial.c
+++ b/MdeModulePkg/Bus/Pci/PciSioSerialDxe/Serial.c
@@ -982,7 +982,7 @@ SerialControllerDriverStart (
             &Supports
             );
           if (!EFI_ERROR (Status)) {
-            Supports &= EFI_PCI_IO_ATTRIBUTE_IO | EFI_PCI_IO_ATTRIBUTE_MEMORY;
+            Supports &= (UINT64)(EFI_PCI_IO_ATTRIBUTE_IO | EFI_PCI_IO_ATTRIBUTE_MEMORY);
             Status = ParentIo.PciIo->Attributes (
               ParentIo.PciIo,
               EfiPciIoAttributeOperationEnable,