diff --git a/.pytool/Plugin/UncrustifyCheck/Readme.md b/.pytool/Plugin/UncrustifyCheck/Readme.md
index 0c46fd241a..efe7a573e4 100644
--- a/.pytool/Plugin/UncrustifyCheck/Readme.md
+++ b/.pytool/Plugin/UncrustifyCheck/Readme.md
@@ -41,6 +41,7 @@ The plugin can be configured with a few optional configuration options.
       "AdditionalIncludePaths": [], # Additional paths to check formatting (wildcards supported).
       "AuditOnly": False,           # Don't fail the build if there are errors.  Just log them.
       "ConfigFilePath": "",         # Custom path to an Uncrustify config file.
+      "IgnoreFiles": [],            # A list of file patterns to ignore.
       "IgnoreStandardPaths": [],    # Standard Plugin defined paths that should be ignored.
       "OutputFileDiffs": True,      # Output chunks of formatting diffs in the test case log.
                                     # This can significantly slow down the plugin on very large packages.
@@ -67,6 +68,12 @@ the test as skipped. This allows visibility into the failures without breaking t
 
 When specified in the config file, this is a package relative path to the Uncrustify configuration file.
 
+### `IgnoreFiles`
+
+This option supports .gitignore file and folder matching strings including wildcards.
+
+The files specified by this configuration option will not be processed by Uncrustify.
+
 ### `IgnoreStandardPaths`
 
 This plugin by default will check the below standard paths. A package configuration file can specify any of these paths
diff --git a/.pytool/Plugin/UncrustifyCheck/UncrustifyCheck.py b/.pytool/Plugin/UncrustifyCheck/UncrustifyCheck.py
index 6920580646..22cca0ff11 100644
--- a/.pytool/Plugin/UncrustifyCheck/UncrustifyCheck.py
+++ b/.pytool/Plugin/UncrustifyCheck/UncrustifyCheck.py
@@ -18,6 +18,7 @@ from edk2toolext.environment.plugin_manager import PluginManager
 from edk2toolext.environment.plugintypes.ci_build_plugin import ICiBuildPlugin
 from edk2toolext.environment.plugintypes.uefi_helper_plugin import HelperFunctions
 from edk2toolext.environment.var_dict import VarDict
+from edk2toollib.gitignore_parser import parse_gitignore_lines
 from edk2toollib.log.junit_report_format import JunitReportTestCase
 from edk2toollib.uefi.edk2.path_utilities import Edk2Path
 from edk2toollib.utility_functions import  RunCmd
@@ -273,6 +274,24 @@ class UncrustifyCheck(ICiBuildPlugin):
             f"-c {self._app_config_file} -F {self._app_input_file_path} --if-changed --suffix {UncrustifyCheck.FORMATTED_FILE_EXTENSION}", outstream=output)
         self._app_output = output.getvalue().strip().splitlines()
 
+    def _get_files_ignored_in_config(self):
+        """"
+        Returns a function that returns true if a given file string path is ignored in the plugin configuration file and false otherwise.
+        """
+        ignored_files = []
+        if "IgnoreFiles" in self._package_config:
+            ignored_files = self._package_config["IgnoreFiles"]
+
+        # Pass "Package configuration file" as the source file path since
+        # the actual configuration file name is unknown to this plugin and
+        # this provides a generic description of the file that provided
+        # the ignore file content.
+        #
+        # This information is only used for reporting (not used here) and
+        # the ignore lines are being passed directly as they are given to
+        # this plugin.
+        return parse_gitignore_lines(ignored_files, "Package configuration file", self._abs_workspace_path)
+
     def _get_git_ignored_paths(self) -> List[str]:
         """"
         Returns a list of file absolute path strings to all files ignored in this git repository.
@@ -465,6 +484,19 @@ class UncrustifyCheck(ICiBuildPlugin):
             self._abs_file_paths_to_format.extend(
                 [str(path.resolve()) for path in pathlib.Path(self._abs_package_path).rglob(path)])
 
+        # Remove files ignore in the plugin configuration file
+        plugin_ignored_files = list(filter(self._get_files_ignored_in_config(), self._abs_file_paths_to_format))
+
+        if plugin_ignored_files:
+            logging.info(
+                f"{self._package_name} file count before plugin ignore file exclusion: {len(self._abs_file_paths_to_format)}")
+            for path in plugin_ignored_files:
+                if path in self._abs_file_paths_to_format:
+                    logging.info(f"  File ignored in plugin config file: {path}")
+                    self._abs_file_paths_to_format.remove(path)
+            logging.info(
+                f"{self._package_name} file count after plugin ignore file exclusion: {len(self._abs_file_paths_to_format)}")
+
         if not "SkipGitExclusions" in self._package_config or not self._package_config["SkipGitExclusions"]:
             # Remove files ignored by git
             logging.info(