diff --git a/CryptoPkg/Library/Include/CrtLibSupport.h b/CryptoPkg/Library/Include/CrtLibSupport.h
index f36fe08f0c..76591f12cb 100644
--- a/CryptoPkg/Library/Include/CrtLibSupport.h
+++ b/CryptoPkg/Library/Include/CrtLibSupport.h
@@ -424,4 +424,19 @@ strcpy (
 #define atoi(nptr)              AsciiStrDecimalToUintn(nptr)
 #define gettimeofday(tvp, tz)   do { (tvp)->tv_sec = time(NULL); (tvp)->tv_usec = 0; } while (0)
 
+//
+// only use in Mbedlts. The Openssl has defined them internally.
+//
+#ifndef OPENSSL_SYS_UEFI
+typedef INT8   int8_t;
+typedef UINT8  uint8_t;
+typedef INT16  int16_t;
+typedef UINT16 uint16_t;
+typedef INT32  int32_t;
+typedef UINT32 uint32_t;
+typedef INT64  int64_t;
+typedef UINT64 uint64_t;
+typedef UINTN  uintptr_t;
+#endif
+
 #endif
diff --git a/CryptoPkg/Library/Include/stdint.h b/CryptoPkg/Library/Include/stdint.h
index 17b8c767d7..786d57e8d5 100644
--- a/CryptoPkg/Library/Include/stdint.h
+++ b/CryptoPkg/Library/Include/stdint.h
@@ -7,13 +7,3 @@ SPDX-License-Identifier: BSD-2-Clause-Patent
 **/
 
 #include <CrtLibSupport.h>
-
-typedef INT8    int8_t;
-typedef UINT8   uint8_t;
-typedef INT16   int16_t;
-typedef UINT16  uint16_t;
-typedef INT32   int32_t;
-typedef UINT32  uint32_t;
-typedef INT64   int64_t;
-typedef UINT64  uint64_t;
-typedef UINTN   uintptr_t;