diff --git a/CryptoPkg/Driver/Crypto.c b/CryptoPkg/Driver/Crypto.c
index d9096ea603..26f280cd5d 100644
--- a/CryptoPkg/Driver/Crypto.c
+++ b/CryptoPkg/Driver/Crypto.c
@@ -243,7 +243,7 @@ DeprecatedCryptoServiceMd4HashAll (
   return BaseCryptLibServiceDeprecated ("Md4HashAll"), FALSE;
 }
 
-#ifdef DISABLE_MD5_DEPRECATED_INTERFACES
+#ifndef ENABLE_MD5_DEPRECATED_INTERFACES
 /**
   Retrieves the size, in bytes, of the context buffer required for MD5 hash operations.
 
@@ -4494,7 +4494,7 @@ const EDKII_CRYPTO_PROTOCOL mEdkiiCrypto = {
   DeprecatedCryptoServiceMd4Update,
   DeprecatedCryptoServiceMd4Final,
   DeprecatedCryptoServiceMd4HashAll,
-#ifdef DISABLE_MD5_DEPRECATED_INTERFACES
+#ifndef ENABLE_MD5_DEPRECATED_INTERFACES
   /// Md5 - deprecated and unsupported
   DeprecatedCryptoServiceMd5GetContextSize,
   DeprecatedCryptoServiceMd5Init,
diff --git a/CryptoPkg/Include/Library/BaseCryptLib.h b/CryptoPkg/Include/Library/BaseCryptLib.h
index ae9bde9e37..496121e6a4 100644
--- a/CryptoPkg/Include/Library/BaseCryptLib.h
+++ b/CryptoPkg/Include/Library/BaseCryptLib.h
@@ -72,7 +72,7 @@ typedef enum {
 //    One-Way Cryptographic Hash Primitives
 //=====================================================================================
 
-#ifndef DISABLE_MD5_DEPRECATED_INTERFACES
+#ifdef ENABLE_MD5_DEPRECATED_INTERFACES
 /**
   Retrieves the size, in bytes, of the context buffer required for MD5 hash operations.
 
diff --git a/CryptoPkg/Library/BaseCryptLib/Hash/CryptMd5.c b/CryptoPkg/Library/BaseCryptLib/Hash/CryptMd5.c
index b85e7f4d12..d670f17424 100644
--- a/CryptoPkg/Library/BaseCryptLib/Hash/CryptMd5.c
+++ b/CryptoPkg/Library/BaseCryptLib/Hash/CryptMd5.c
@@ -9,7 +9,7 @@ SPDX-License-Identifier: BSD-2-Clause-Patent
 #include "InternalCryptLib.h"
 #include <openssl/md5.h>
 
-#ifndef DISABLE_MD5_DEPRECATED_INTERFACES
+#ifdef ENABLE_MD5_DEPRECATED_INTERFACES
 /**
   Retrieves the size, in bytes, of the context buffer required for MD5 hash operations.
 
diff --git a/CryptoPkg/Library/BaseCryptLibOnProtocolPpi/CryptLib.c b/CryptoPkg/Library/BaseCryptLibOnProtocolPpi/CryptLib.c
index 3f14c6d262..8b43d1363c 100644
--- a/CryptoPkg/Library/BaseCryptLibOnProtocolPpi/CryptLib.c
+++ b/CryptoPkg/Library/BaseCryptLibOnProtocolPpi/CryptLib.c
@@ -99,7 +99,7 @@ CryptoServiceNotAvailable (
 //    One-Way Cryptographic Hash Primitives
 //=====================================================================================
 
-#ifndef DISABLE_MD5_DEPRECATED_INTERFACES
+#ifdef ENABLE_MD5_DEPRECATED_INTERFACES
 /**
   Retrieves the size, in bytes, of the context buffer required for MD5 hash operations.