diff --git a/BaseTools/Source/Python/AutoGen/ModuleAutoGenHelper.py b/BaseTools/Source/Python/AutoGen/ModuleAutoGenHelper.py
index 8e60643d1f..7477b1d77f 100644
--- a/BaseTools/Source/Python/AutoGen/ModuleAutoGenHelper.py
+++ b/BaseTools/Source/Python/AutoGen/ModuleAutoGenHelper.py
@@ -1,7 +1,7 @@
 ## @file
 # Create makefile for MS nmake and GNU make
 #
-# Copyright (c) 2019, Intel Corporation. All rights reserved.<BR>
+# Copyright (c) 2019 - 2021, Intel Corporation. All rights reserved.<BR>
 # SPDX-License-Identifier: BSD-2-Clause-Patent
 #
 from __future__ import absolute_import
@@ -178,8 +178,11 @@ class AutoGenInfo(object):
                 if ToolDef[Tool].get(TAB_TOD_DEFINES_BUILDRULEFAMILY, "") != "":
                     if Family != ToolDef[Tool][TAB_TOD_DEFINES_BUILDRULEFAMILY]:
                         continue
-                elif Family != ToolDef[Tool][TAB_TOD_DEFINES_FAMILY]:
-                    continue
+                else:
+                    if ToolDef[Tool].get(TAB_TOD_DEFINES_FAMILY, "") == "":
+                        continue
+                    if Family != ToolDef[Tool][TAB_TOD_DEFINES_FAMILY]:
+                        continue
                 FamilyMatch = True
             # expand any wildcard
             if Target == TAB_STAR or Target == self.BuildTarget:
@@ -213,6 +216,8 @@ class AutoGenInfo(object):
             if Tool not in ToolDef or Family == "":
                 continue
             # option has been added before
+            if TAB_TOD_DEFINES_FAMILY not in ToolDef[Tool]:
+                continue
             if Family != ToolDef[Tool][TAB_TOD_DEFINES_FAMILY]:
                 continue
 
diff --git a/BaseTools/Source/Python/AutoGen/PlatformAutoGen.py b/BaseTools/Source/Python/AutoGen/PlatformAutoGen.py
index c16f2e4cd8..e2ef325677 100644
--- a/BaseTools/Source/Python/AutoGen/PlatformAutoGen.py
+++ b/BaseTools/Source/Python/AutoGen/PlatformAutoGen.py
@@ -1474,8 +1474,11 @@ class PlatformAutoGen(AutoGen):
                 if ToolDef[Tool].get(TAB_TOD_DEFINES_BUILDRULEFAMILY, "") != "":
                     if Family != ToolDef[Tool][TAB_TOD_DEFINES_BUILDRULEFAMILY]:
                         continue
-                elif Family != ToolDef[Tool][TAB_TOD_DEFINES_FAMILY]:
-                    continue
+                else:
+                    if ToolDef[Tool].get(TAB_TOD_DEFINES_FAMILY, "") == "":
+                        continue
+                    if Family != ToolDef[Tool][TAB_TOD_DEFINES_FAMILY]:
+                        continue
                 FamilyMatch = True
             # expand any wildcard
             if Target == TAB_STAR or Target == self.BuildTarget:
@@ -1509,6 +1512,8 @@ class PlatformAutoGen(AutoGen):
             if Tool not in ToolDef or Family == "":
                 continue
             # option has been added before
+            if TAB_TOD_DEFINES_FAMILY not in ToolDef[Tool]:
+                continue
             if Family != ToolDef[Tool][TAB_TOD_DEFINES_FAMILY]:
                 continue