diff --git a/CryptoPkg/Library/Include/openssl/opensslconf.h b/CryptoPkg/Library/Include/openssl/opensslconf.h
index 70d24f99ac..f55b27ae81 100644
--- a/CryptoPkg/Library/Include/openssl/opensslconf.h
+++ b/CryptoPkg/Library/Include/openssl/opensslconf.h
@@ -73,6 +73,9 @@ extern "C" {
 #ifndef OPENSSL_NO_RC2
 # define OPENSSL_NO_RC2
 #endif
+#ifndef OPENSSL_NO_RC4
+# define OPENSSL_NO_RC4
+#endif
 #ifndef OPENSSL_NO_RC5
 # define OPENSSL_NO_RC5
 #endif
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLib.inf b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
index 10710e4a7c..dfaefd1c08 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLib.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
@@ -374,8 +374,6 @@
   $(OPENSSL_PATH)/crypto/rand/rand_unix.c
   $(OPENSSL_PATH)/crypto/rand/rand_vms.c
   $(OPENSSL_PATH)/crypto/rand/rand_win.c
-  $(OPENSSL_PATH)/crypto/rc4/rc4_enc.c
-  $(OPENSSL_PATH)/crypto/rc4/rc4_skey.c
   $(OPENSSL_PATH)/crypto/rsa/rsa_ameth.c
   $(OPENSSL_PATH)/crypto/rsa/rsa_asn1.c
   $(OPENSSL_PATH)/crypto/rsa/rsa_chk.c
@@ -531,7 +529,6 @@
   $(OPENSSL_PATH)/crypto/ocsp/ocsp_lcl.h
   $(OPENSSL_PATH)/crypto/pkcs12/p12_lcl.h
   $(OPENSSL_PATH)/crypto/rand/rand_lcl.h
-  $(OPENSSL_PATH)/crypto/rc4/rc4_locl.h
   $(OPENSSL_PATH)/crypto/rsa/rsa_locl.h
   $(OPENSSL_PATH)/crypto/sha/sha_locl.h
   $(OPENSSL_PATH)/crypto/siphash/siphash_local.h
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf b/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
index d9782a3098..080e1d9305 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
@@ -374,8 +374,6 @@
   $(OPENSSL_PATH)/crypto/rand/rand_unix.c
   $(OPENSSL_PATH)/crypto/rand/rand_vms.c
   $(OPENSSL_PATH)/crypto/rand/rand_win.c
-  $(OPENSSL_PATH)/crypto/rc4/rc4_enc.c
-  $(OPENSSL_PATH)/crypto/rc4/rc4_skey.c
   $(OPENSSL_PATH)/crypto/rsa/rsa_ameth.c
   $(OPENSSL_PATH)/crypto/rsa/rsa_asn1.c
   $(OPENSSL_PATH)/crypto/rsa/rsa_chk.c
@@ -531,7 +529,6 @@
   $(OPENSSL_PATH)/crypto/ocsp/ocsp_lcl.h
   $(OPENSSL_PATH)/crypto/pkcs12/p12_lcl.h
   $(OPENSSL_PATH)/crypto/rand/rand_lcl.h
-  $(OPENSSL_PATH)/crypto/rc4/rc4_locl.h
   $(OPENSSL_PATH)/crypto/rsa/rsa_locl.h
   $(OPENSSL_PATH)/crypto/sha/sha_locl.h
   $(OPENSSL_PATH)/crypto/siphash/siphash_local.h
diff --git a/CryptoPkg/Library/OpensslLib/process_files.pl b/CryptoPkg/Library/OpensslLib/process_files.pl
index bd4a84da24..254bc4dbcc 100755
--- a/CryptoPkg/Library/OpensslLib/process_files.pl
+++ b/CryptoPkg/Library/OpensslLib/process_files.pl
@@ -80,6 +80,7 @@ BEGIN {
                 "no-poly1305",
                 "no-posix-io",
                 "no-rc2",
+                "no-rc4",
                 "no-rfc3779",
                 "no-rmd160",
                 "no-scrypt",